Endocrine Abstracts

Introduction: Children with Down’s Syndrome (DS) have altered immunity with higher rates of diabetes, thyroid autoimmunity, coeliac disease, respiratory tract infections and leukemia. Diabetes in children with DS appears to be accelerated with an earlier age of onset compared with the general population, with 22% diagnosed before the age of 2 years. Increased HLA class II DR3/4 susceptibility is seen in in children with DS and diabetes but the prevalence is reduced compar...

Background: General population screening for type 1 diabetes (T1D) using islet autoantibodies (IAb) is gaining international momentum, since screening reduces diabetic ketoacidosis, hospitalisation and identifies individuals eligible for future preventative treatments. Qualitative studies have only been undertaken in at-risk individuals (1). We therefore aimed to explore parents’ experiences of their child taking part in a general population T1D screening...